Human and nonhuman blood serum containing antibodies against Salmonella bacterial antigens; can be used in clinical diagnostic procedures, or injected as a means of treating or protecting against Salmonella infections.
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A potent inhibitor of PI3K with selectivity for the class IB isoform PI3KY (IC50 70 nM) compared to PI3Ka (IC50 240 nM) PI3KB (IC50 1.45 M) and PI3K (IC50 1.70 M) shows little or no activity against 38 other common kinases
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A ROCK1 inhibitor (IC50 7 nM for the human kinase) selective over RSK1 and p70S6K (IC50s 398 and 1000 nM respectively) and is greater than 100-fold selective over a panel of 31 additional kinases induces relaxation in precontracted isolated rat aortic rings (EC50 256 nM) decreases mean arterial blood pressure in spontaneously hypertensive rats at 30 mg/kg
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An analytical reference standard categorized as a muscle relaxant has been found as an impurity in seized heroin intended for research and forensic applications
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A dual agonist of FXR and PPAR activates FXR and PPAR in reporter assays using HEK293T cells (EC50s 0.94 and 1.5 UM respectively) selective for these receptors over RARa RXRa PPARa PPARY and LXRa at 10 UM
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A T-type calcium channel inhibitor (IC50s 89 92 and 98 nM for Cav3.1 Cav3.2 and Cav3.3 respectively in patch-clamp assays at -80 mV) selective for these channels over Cav1.2 Cav2.1 Cav2.2 and Cav2.3 in patch-clamp assays (IC50s >30 UM for all at -90 mV) reduces the viability of spheroid A549 lung cancer cells at 100 or 200 nM decreases body weight gain and fat mass and increases lean muscle mass in mice fed a high-fat diet inhibits amphetamine- or MK-801-induced locomotor activity in rats at 3 mg/kg decreases the mean time spent in active wake and REM sleep and increases the mean time spent in delta sleep in wild-type but not Cacna1g-/- and Cacna1i-/- double knockout mice when administered one hour before the inactive phase at 10 mg/kg
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